![]() ![]() ![]() Implants should be inserted by trained skilled healthcare providers, and insertion should be preceded by adequate counselling about the contraceptive effect, benefits, and possible AEs. Subdermal implants are a progestin-only (etonogestrel (ENG), levonorgestrel (LNG)) contraceptive consisting of polymer capsules or rods placed under the skin that ensure a slow stable hormone delivery bypassing the first-pass hepatic metabolism they do not contain any oestrogens and do not induce plasma progestin peaks. The aim of the current review is to describe the available evidence about contraceptive implants in the clinical practice, in terms of safety, efficacy, and adverse events (AEs) in reproductive-aged women furthermore, we aimed to evaluate the main evidence about their non-contraceptive effects ( Table 1). Since 1991, when they were first introduced in the United States, progestin-only subdermal implants have become a safe, widespread contraceptive option, providing long-acting, highly effective reversible contraception. Therefore, they are excellent strategies to prevent UPs in all women not desiring a future pregnancy and not wanting a permanent contraception procedure. LARCs offer reversible long-term contraception, characterized by high continuation rates. ![]() Short-acting contraceptive methods (patch, vaginal ring, or oral contraceptives (OCs)) are characterized by impaired adherence, in terms of poor compliance and/or improper intake, with secondary relatively high UP risk.Ĭonversely, long-acting reversible contraceptives (LARCs) (intrauterine devices (IUDs), copper (Cu)-IUD, and subdermal contraceptive implants) provide at least 3-year continuous pregnancy protection and do not require any attention by users. Ĭontraceptive systems represent a safe and effective instrument allowing fertile women who do not desire pregnancy to avoid it, and all women asking for contraception should receive detailed counselling about contraceptive choice. Unplanned pregnancies (UPs) negatively affect the health system, since they not only lead to high social costs due to maternal and/or foetal morbidity, but also to the costs related to legal abortion. More studies are needed to validate the extended use of the ENG implant for up to 5 years. Implants should be inserted by trained skilled clinicians who previously provide adequate counselling about their contraceptive effect, benefits, and any possible adverse events. The ENG implant could be an effective and discrete alternative to the IUD in young girls, such as post-partum/post-abortion. Emerging evidence demonstrated that it is possible to extend the use of the ENG implant beyond the three-year period for which it is approved. Abnormal menstrual bleeding is a common ENG side effect, representing the main reason for its premature discontinuation. The etonogestrel (ENG) single rod dispositive has been widely employed in clinical practice, since it is a highly effective and safe contraceptive method. Levonorgestrel (LNG) 6-capsule subdermal implants represented the first effective system approved for reversible contraception. We searched the medical publications in PubMed, CENTRAL, and EMBASE for relevant articles on hormonal implants published in English between 19. Progestin-only contraceptive implants provide long-acting, highly effective reversible contraception. ![]()
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